PIK3R1 and immunodeficiency 36 with lymphoproliferation: Whole genome sequencing revealed a previously reported (8–10) de novo heterozygous pathogenic splice mutation in a mutation hotspot of PIK3R1 (c.1425 + 1G > A), resulting in the skipping of exon 11 of the p85α subunit of phosphatidylinositol 3-kinase and confirming the diagnosis of activated PI3Kδ syndrome type II (APDS2).