Vasculitis has never been described in APDS2 (although lupus-like features have) (8), but is almost certainly an autoimmune feature of APDS2 in the proband, particularly since we recently described cutaneous vasculitis in a young child with megacephaly driven by mutation in PTEN, another important gene in the same pathway (18). The gene discussed is PTEN; the disease is systemic lupus erythematosus.