Genetic modulation of another KP enzyme, KMO has also proven to be two sided: inhibition was found to be protective against EMCV infection in a mouse model of viral myocarditis (41), however, lack of KMO was reported to lead to autoimmune disease exacerbation (42) and also caused malfunction of podocytes in the kidney and consequent proteinuria (43). This evidence concerns the gene KMO and autoimmune disease.