NOS2 and hyperinsulinemic hypoglycemia, familial, 4: Wls-deficiency in BMDMs of Wlsfl/fl-Lyz2-Cre mice has been reported to significantly increase mRNA expression of inducible nitric oxide synthase (iNOS, encoded by Nos2) (137), a phenotype also observed in macrophages isolated from myocardial infarct tissue of cfms-icre Wlsfl/fl mice (138).