In an OVA-expressing tumor model, Wnt1-overexpression by DCs was associated with reduced T cell receptor stimulation, granzyme B secretion and cytotoxicity by CD8+ T cells (186), whereas conditional knockout of LRP5/LRP6 in CD11c+ cells resulted in an increase in granzyme B production by CD8+ T cells (185). This evidence concerns the gene GZMB and neoplasm.