CD4 and autoimmune lymphoproliferative syndrome: Such a polyclonal DN T-cell repertoire as found in our CD4-deficient patient (and in CD4 KO mice) is different from the typically restricted TCRVβ repertoire observed in DN T-cells from healthy mice and humans (51) and from autoimmune lymphoproliferative syndrome (ALPS) patients (52), which usually contain expanded clones of MHC/HLA class I–related T-cells.