We found that 60% of the adult cohort and 100% of the elderly cohort presented with comorbidities, with diabetes mellitus in 10% (1/10) and 54% (7/13) of cases (mainly early-stage, 6 non-insulin, and 2 insulin-dependent), respectively, followed by hypertension and other cardiovascular complications. The gene discussed is INS; the disease is hypertensive disorder.