Examples of these include promyelocytic leukemia protein-nuclear body (PML-NB) constituent proteins (e.g., promyelocytic leukemia, PML; speckled 100 kDa, Sp100; death domain associated protein, Daxx; alpha thalassemia/mental retardation syndrome X-linked, ATRX; and MORC family CW-type zinc finger 3, MORC3), E3 SUMO ligases [e.g., protein inhibitor of activated STAT (PIAS) 1 and 4; PIAS1 and PIAS4, respectively], DNA repair proteins (e.g., ring finger protein-8 and -168; RNF8 and RNF168, respectively), and epigenetic regulators (e.g., repressive histones) (Figure 3). The gene discussed is ATRX; the disease is acute promyelocytic leukemia.