Recent studies have shown that the main reasons why the body’s interferon-beta (IFN-β) cannot fully exert its antiviral effect after TGEV infection are as follows: First, the cells do not respond in time to the immune response because of the level of viral replication and the virus titer of TGEV in the early stage of infection, resulting in lower levels of IFNs, which is the main cause of the short burst of TGEV latency (Zhu et al., 2017). This evidence concerns the gene IFNB1 and infection.