ZNRF3 and adrenal cortex carcinoma: Two examples are the histone methyltransferase Enhancer of Zeste Homolog 2 (Ezh2), the most deregulated epigenetic factor in adrenocortical carcinomas (118) and the transmembrane E3 ubiquitin ligase zinc and ring finger 3 (Znrf3), a known Wnt inhibitor which is frequently inactivated in adrenocortical carcinomas (119).