The frequencies of the PL + LL genotype (14.1 vs. 8.4%) and L allele (7.3 vs. 4.4%) of GPx1 P198L polymorphism were significantly higher in the PCOS group compared with the control group (OR = 1.671, 95% CI: 1.190–2.346, P = 0.003). Here, GPX1 is linked to polycystic ovary syndrome.