In the present study, we investigated the relationships between GPx1 P198L and CAT C-262T variants and the risk of PCOS, evaluated the effects of the genotypes on clinical, hormonal, metabolic and oxidative stress parameters, and analyzed the associations of the genotype combinations of GPx1 P198L and SOD2 A16V with PCOS in well-characterized Chinese women using relatively large sample sizes. Here, GPX1 is linked to polycystic ovary syndrome.