We also found that patients carrying the L allele carriers (PL+LL genotype) of the GPx1 P198L polymorphism had relatively high average ovarian volume, waist circumference, and MDA levels, but lower acne grade score compared with patients carrying the PP genotype, suggesting that increased risk of PCOS in patients with the P198L variant may be potentially linked to ovarian functional abnormalities and increasing levels of oxidative stress in patients. The gene discussed is GPX1; the disease is acne.