Waist circumference, waist-to-hip ratio, F-G score, acne grade score, DBP, average ovarian volume, TT levels, the ratio of LH to FSH, FAI, fasting insulin concentration, HOMA index, TG, TC, LDL-C, TOS, T-AOC, and MDA levels, and OSI were significantly higher, whereas SHBG and HDL-C levels were significantly lower in the PCOS group compared with the control group after adjusting for age and BMI (Table 1). This evidence concerns the gene SHBG and acne.