UCN3 and type 2 diabetes mellitus: The main findings of this study are: (1) plasma UCN3 levels decreased with BMI; (2) UCN3 plasma levels were independently associated with glycemic index (FPG, HbA1c) and were significantly different between overweight individuals with and without T2D; (3) the UCN3 expression in SAT was increased with BMI and blunted with T2D; and (4) a 3-month supervised exercise protocol showed a significant reduction of UCN3 expression in both overweight group SAT.