Similar pattern have been observed in our previous work on the heat shock protein 60 (HSP60) were attenuated in normal-weight subjects with diabetes, in comparison with non-diabetic controls, along with increased expression of the inflammatory markers IL-6 and TNF-α, as observed in our overweight subjects (25).This suggests an autocrine/paracrine role of UCN3 in SAT which is further supported by the opposite trend observed in plasma. This evidence concerns the gene HSPD1 and diabetes mellitus.