PLCXD3 and Hyperglycemia: As illustrated in Figure 2H, the PLCXD3 expression level was significantly unchanged at 16.7 mM glucose as compared to control cells, while at 22.2 mM glucose, we observed increased PLCXD3 expression (Figure 2H), indicating that the observed reduction of PLCXD3 expression in diabetic islets is not due to short-term hyperglycemia.