Progressive damage to the endocrine pancreas, resulting from protein accumulation (consequent to CFTR dysfunction) and precipitation within the pancreatic ducts that causes ductal destruction and ischemic damage (Laguna et al., 2010; Gibson-Corley et al., 2016), leads to the occurrence of CFRD in a majority of individuals with CF, which is clinically distinct from traditional Type 1 and Type 2 diabetes mellitus in non-CF populations. The gene discussed is CFTR; the disease is cystic fibrosis.