CFTR and cystic fibrosis: The effects of CFTR modulator therapies on extra-pulmonary CF disease manifestations are less clear, and, in particular, it is still unclear whether CFTR modulators can improve diabetic status (Bellin et al., 2013; Tsabari et al., 2016; Thomassen et al., 2018; Kelly et al., 2019; Li et al., 2019).