Furthermore, it has been reported that TWEAK/Fn14/NF-κB pathway plays an important role in asthma airway inflammation of asthma (Kim et al., 2018; Zhu and Zhang, 2018), and can induce proliferation and migration of human airway smooth muscle cells (ASMCs) (Zhu and Zhang, 2018). This evidence concerns the gene TNFRSF12A and asthma.