CD4+ T cells have been shown to elicit cytotoxicity and tumor rejection dependent on MHC class II-restricted recognition of tumors by tumor-reactive CD4+ T cells (Homma et al., 2005; Quezada et al., 2010) and participate in the anti-tumor immunity (Quezada et al., 2010; Xie et al., 2010). Here, CD4 is linked to neoplasm.