Rh2 has especially gained attention for its broad-spectrum anti-proliferative effect on a variety of human cancer cells (Oh et al., 1999; Kim et al., 2004; Qi et al., 2011; Guo et al., 2014; Shi et al., 2014; Qian et al., 2016; Yang et al., 2016; Wang et al., 2018). The gene discussed is RHAG; the disease is cancer.