Reports have demonstrated that mTOR can facilitate PI3K/Akt-induced NF-κB activation (Peppenelli et al., 2018; Altman et al., 2019), an important step in all the three stages of HCMV infection (Li et al., 2015; Peppenelli et al., 2018; Altman et al., 2019) (https://www.kegg.jp/kegg-bin/highlight_pathway?scale=1.0&map=map05163&keyword=human%20herpesvirus%203). This evidence concerns the gene NFKB1 and cytomegalovirus infection.