The nod-like receptor protein 3 (NLRP3) inflammasome, a promoter involved in innate immune response initiation, has been reported to participate in the progression of many neurodegenerative diseases, including MS (Inoue and Shinohara, 2013; Song et al., 2017; Wang et al., 2019). The gene discussed is NLRP3; the disease is myeloid sarcoma.