In the CNS, ghrelin also plays these important roles, which has been verified experimentally in animal models of cerebral ischemia, traumatic brain injury, acute spinal cord injury, epilepsy, Parkinson’s disease, and Alzheimer’s disease (Moon et al., 2009; Lee et al., 2010; Portelli et al., 2012; Kenny et al., 2013; Cecarini et al., 2016; Shi et al., 2017b). This evidence concerns the gene GHRL and early-onset autosomal dominant Alzheimer disease.