AKT1 and breast carcinoma: In search of anticancer drugs whose activity could be enhanced by WZB117, we found that the combination of MK-2206 and WZB117 showed the best synergistic cytotoxic effect against breast cancer cells, and further investigation revealed that MK-2206 and WZB117 exerted cytotoxic effect through inhibition of Akt, induction of ROS and DNA damage, as well as impairment of DNA damage repair.