Results show that PI3K-Akt, focal adhesion, microRNAs in cancer, cytokine–cytokine receptor interaction, and Jak-STAT signaling pathway are the most affected pathways by CuC in HepG2 cells, whereas in PC-3 cells, microRNAs, cytokine–cytokine receptor interaction, and PI3K-Akt signaling pathways were also changed. This evidence concerns the gene AKT1 and cancer.