MAPT and epilepsy: It must also be acknowledged that epilepsy and seizure activity have been repeatedly shown to have dramatic effects on post-transcriptional regulation via microRNAs, which could be implicated in the changes in tau expression observed in this study with various microRNAs altered in epilepsy models also known to target tau (Jimenez-Mateos and Henshall, 2013; Santa-Maria et al., 2015; Zheng et al., 2016).