MAPT and Mental deterioration: TLE is the most common form of acquired epilepsy in adults and particularly prone to pharmacoresistance (Schmidt and Löscher, 2005) and, although not defined as a neurodegenerative disease, tau-based aggregates which directly correlate with cognitive decline have been identified in TLE patient brain (Thom et al., 2011; Tai et al., 2016, p. 4).