CHRNA7 and Parkinson disease: As found in the in vivo PD animal model (Liu et al., 2017) and in vitro SH-SY5Y cells (Xu et al., 2019), α7nAChR deficiency/knockdown did not affect the neurotoxicity of MPP+ both in cell viability (Figure 5A; WT: 100.6% ± 0.8 in control and 75.0% ± 1.6 in MPP+ alone, KO: 100.4% ± 2.2 in control and 74.1% ± 2.3 in MPP+ alone) and LDH leakage (Figure 5B; WT: 100.4% ± 1.1 in control and 155.6% ± 2.1 in MPP+ alone, KO: 99.5% ± 0.8 in control and 154.9% ± 1.7 in MPP+ alone).