GJA1 and experimental autoimmune encephalomyelitis: Mice with a selective astrocytic Cx43 deficiency or with this deficiency in a global Cx30 knockout background to prevent compensatory effects were not statistically different from wild type mice in terms of a clinical score that evaluates the severity and time course of the motor signs of experimental autoimmune encephalomyelitis up to 3–4 weeks after immunization (Lutz et al., 2012).