Interestingly, Cx32 knockout mice bearing a human Cx32 mutation associated with central manifestations of X-linked Charcot-Marie-Tooth disease (Cx32KOT55I) display an enhanced widespread central nervous system inflammatory response not associated with oligodendrocyte loss after lipopolysaccharide challenge, when compared with Cx32 knockout mice that do not carry this mutation (Olympiou et al., 2016). Here, GJB1 is linked to X-linked Charcot-Marie-Tooth disease.