Mice with a selective astrocytic Cx43 deficiency or with this deficiency in a global Cx30 knockout background to prevent compensatory effects were not statistically different from wild type mice in terms of a clinical score that evaluates the severity and time course of the motor signs of experimental autoimmune encephalomyelitis up to 3–4 weeks after immunization (Lutz et al., 2012). This evidence concerns the gene GJB6 and experimental autoimmune encephalomyelitis.