CXCL8 and ischemia: The n-6 PUFAs downregulate the expression of chemoattractant production C-X-C motif ligand-1 (CXCL1) and C-C motif ligand-2 (CCL2) on intestinal ischemia/reperfusion injury [43], as well as n-3 PUFAs inhibit chemokine production such as interleukin-8 (also known as CXCL8) [41].