Other studies have clarified the presence of cytokine (IL-6 and IL-22)-responsive elements in the promoter regions of REG Iα and Iβ and HIP/PAP in pancreatic or colon cancer cells [32, 40], although it remained unclear whether STAT3 and/or other transcriptional factors actually bind to these elements. This evidence concerns the gene IL6 and malignant colon neoplasm.