Levels of TNF-α, TLR4, ACR, MDA, and hs-CRP were remarkably increased (P < 0.001), and levels of SDF-1α, SOD3, and eNOS were remarkably lowered (P < 0.001) in elderly patients with severe coronary stenosis and multiple coronary chronic total occlusions. This evidence concerns the gene TLR4 and coronary stenosis.