These findings suggested that increased levels of TNF-α, TLR4, ACR, MDA, and hs-CRP were associated with severe coronary stenosis and multiple coronary chronic total occlusions in elderly patients with coronary artery disease, and the coronary stent implantation was associated with side effects ranging from severe coronary stenosis to multiple coronary chronic total occlusions in the elderly patients via induced proinflammatory and prooxidative stress mediators. The gene discussed is TLR4; the disease is coronary stenosis.