Our findings showed that the increased levels of TNF-α, TLR4, ACR, MDA, and hs-CRP as proinflammatory and prooxidant mediators markedly inhibited the levels of SDF-1α, SOD3, and eNOS as anti-inflammatory/antioxidant mediators in patients with severe coronary stenosis and multiple coronary chronic total occlusions. The gene discussed is TNF; the disease is coronary stenosis.