IL6 and Sepsis: By using a murine model of sepsis with caecal ligation and puncture inducing colonic barrier dysfunction, Nullens et al. showed that the damaging effects on the barrier function were counteracted when the animal was preventively treated with the anti-IL-6 antibody, coinciding with reduced serum levels of IL-6 and IL-10 and colonic level of TNF-α [59].