Roy Fleischmann and his colleagues have reported that the most common adverse permanent discontinuation events were elevated alanine aminotransferase (ALT) (0-2.9%) and elevated aspartate aminotransferase (AST) (0-2.9%) and serious infection events including pneumonia, herpes zoster, pyelonephritis, pneumococcal sepsis, ankle-joint infection, respiratory tract infection, urinary tract infection, infectious gastroenteritis, and the exacerbation of Whipple's disease that occurred at a rate of 0-5.4% [14, 31]. This evidence concerns the gene GPT and urinary tract infection.