TNF and Sepsis: A disintegrin and metalloproteinase 10 (ADAM10) is involved in the shedding of more than 40 cellular substrates, including CX3CL1, IL-6R, and TNF-α, and influences the release of the inflammatory cytokines IL-6 and IL-1β in activated neutrophils, monocytes, and macrophages, which have been theorized to play pivotal roles in sepsis [5–7].