GSEA using gene sets up- or downregulated during PMA-induced terminal differentiation of THP1 AML cells into macrophages (Table S4) [17] demonstrated that the transcriptional changes observed in OG-98/RAD001-treated vs. DMSO vehicle-treated primary MLL-translocated AML cells were similar (Fig. 3c). This evidence concerns the gene KMT2A and acute myeloid leukemia.