Specifically, there was significant overlap of the Group B gene sets upregulated following combination treatment in THP1 AML cells and primary patient AML cell xenografts by comparison with control cells (Fig. 3f), and these genes included those coding for 13 transcription factors including those with significant roles in monocyte/macrophage differentiation, such as MAFB, KLF6, EGR1 and EGR3, although not IRF8 [20]. Here, IRF8 is linked to acute myeloid leukemia.