Interestingly, we also observed the strongest depletion of a gene set associated with leukaemia stem cell maintenance in murine MLL-AF9 AML cells in the OG-86/RAD001 vs. DMSO comparison, as well as the strongest upregulation of genes whose expression is anti-correlated with leukaemia stem cell activity (Fig. S5A–C, Table S4) [19]. Here, KMT2A is linked to acute myeloid leukemia.