As for THP1 cells (Fig. 2g), immune-associated gene sets characteristic of terminally differentiated monocytes and macrophages were most strongly upregulated in AML cells recovered from mice treated with the OG-98/RAD001 combination (Fig. 3e); similar findings were noted for genes whose expression is anti-correlated with MLL-AF9 leukaemic stem cell activity (Fig. S5D–F). Here, MLLT3 is linked to acute myeloid leukemia.