RPTOR and Pancytopenia: It is interesting to note that following deletion in haematopoietic stem cells of Rptor, which codes for the substrate-guiding subunit of the mTORC1 complex, mice develop a modest pancytopenia with increased monocytoid cells in bone marrow and spleen [31] suggesting that mTORC1 signalling influences cell fate in granulocyte-monocyte/macrophage progenitor cells.