PTPRC and acute myeloid leukemia: Fourteen weeks later, when circulating human AML cells could be detected in a majority of animals, mice were allocated to four groups balanced for human CD45+ blood chimerism and treated via oral gavage with either vehicle (H2O), RAD001 (5 mg/kg), OG-98 (3 mg/kg) or a combination of RAD001 (5 mg/kg) and OG-98 (3 mg/kg) for 5 days.