ZMPSTE24 and familial partial lipodystrophy: The former is caused by genetic defects or some syndromes disrupting adipogenesis and differentiation, lipid droplet formation as well as adipocyte apoptosis, etc. According to the degree of fat loss, congenital lipodystrophy can be divided into two categories: congenital generalized lipodystrophy (CGL) (causative gene: AGPAT2, BSCL2, CAVI, PTRF) and familial partial lipodystrophy (FPLD) (causative gene: PPARG, LMNA, ZMPSTE24, AKT2, CIDEC, etc.)6.