PDK1 and neoplasm: Amounts of p53 (p = 0.014), ERα (p = 0.049), INPP4B (p = 0.001), VEGFR2 (p = 0.017), MSH2 (p = 0.020), and MSH6 (p = 0.012) were significantly higher in R248-mutated samples than in R175-mutated tumours, while CIAP (p = 0.039), PDK1 (p = 0.018), SF2 (p = 0.016), and Tuberin pT1462 (p = 0.015) were significantly higher in samples with R175 mutation than with R248 mutation (Supplementary Table S5).