In multivariate logistic regression analyses for evaluation of variables associated with PCa detection, age (odds ratio [OR], 1.059; 95% confidence interval [CI], 1.035–1.082; P < 0.001), pre-biopsy PSA (OR, 1.041; 95% CI, 1.016–1.066; P = 0.001), prostate volume on TRUS (OR, 0.954; 95% CI, 0.942–0.966, P < 0.001), and PI-RADsV2 category (≥4; OR, 2.506; 95% CI, 1.571–3.995; P < 0.001) were found to be significant predictors (Table 2). Here, KLK3 is linked to posterior cortical atrophy.