Another man in his 50’s with left frontal GBM with methylated MGMT promoter continued to receive extended TMZ treatment after confirmation of no recurrence/residue of the tumor with routine MRI (Fig. 3D, left) but with high Met uptake at the distant ipsilateral superior parietal lobule (Fig. 3D, middle) with a Tmax/Nave value of 2.50 (group 4). The gene discussed is MGMT; the disease is neoplasm.