MGMT and glioblastoma: Currently, the standard of care for newly diagnosed GBM consists of a combination of maximal safe resection with concurrent temozolomide (TMZ) and radiotherapy followed by adjuvant TMZ (five days per month), the Stupp protocol, which yields a median overall survival (OS) ranging from 12.7 to 21.7 months according to the methylation status of O6-methylguanin-DNA methyltransferase (MGMT) gene1.