We noted Cdk6, Ckd14, and Fzd1 amplifications in KPC5, a subclonal splice site mutation in Msh3 in KPC8, Jun and Acer2 amplifications followed by two additional Trp53 mutations in KPTC11, and Myc and Mastl amplifications in association with mutations in Smo and then Bcl9 in KPTC9. In the case of KPTC9, all 12 somatic mutations were present in all three tumor regions, suggesting the Smo and Bcl9 mutations occurred before subclonal sweep caused by the Myc amplification (up to 9-fold increased). The gene discussed is JUN; the disease is neoplasm.