Dietary Bβglucans also reduced renal nSMase2 gene expression, which could extend the renoprotective benefits of this nutritional strategy to hypertensive individuals28, by counteracting angiotensin II-driven-increases in renal nSMase2 or to diabetic nephropathy, by reducing the release to the urine of megalin loaded exosomes29. This evidence concerns the gene SMPD3 and diabetic kidney disease.