SMPD3 and chronic kidney disease: The uremic rats fed the high P diet with Bßglucans had significantly lower median aortic ADAM17 protein (47%) (Fig. 3a,b), ADAM17 and TNFα mRNA levels (80%) (Fig. 3c) and nSMase2 mRNA levels (65%) and activity (55%) compared with the CKD group (Fig. 3d).