In hyperphosphatemic rat CKD, a daily intake of 40 mg of Bβglucans, as barley flour, effectively reduced inflammation-driven renal injury by targeting renal elevations in ADAM17, an enzyme induced by CKD of all etiologies12 and also by TNFα14 and oxidative stress8, despite undetectable serum β-glucan levels. The gene discussed is ADAM17; the disease is chronic kidney disease.