SMPD3 and chronic kidney disease: The internalization of (1,3)β-D-glucans into A7r5 cells exposed to Bβglucans extracts may also occur in other Bβglucans target cells, which could explain in part the systemic, renal and vascular anti-inflammatory/anti-nSMase2 actions of dietary Bβglucans in healthy adults and in hyperphosphatemic rat CKD despite undetectable serum levels.