Dietary Bβglucans suppressed by 80% the self-perpetuating aortic ADAM17/TNFα-inflammatory loop9 and prevented the 3-fold elevations in nSMase2 reported to prompt pro-calcifying exosome release16, thereby reducing aortic calcium deposition in the CKD + Bβglucans group by 8-fold compared to that in uremic controls. This evidence concerns the gene SMPD3 and chronic kidney disease.