M2 macrophages secreted multiple soluble factors, such as fibroblast growth factor 2 (FGF2), growth-regulated oncogene-α (GROα), and macrophage colony-stimulating factor, which not only activated intracellular signals in cancer cells but also promoted laminin secretion by cancer-associated fibroblasts, leading to microenvironmental remodeling and cancer metastasis. The gene discussed is FGF2; the disease is cancer.