Pathway analysis identified deregulation of not only those consistent with previously established ELF3-related signaling events—for example, IL-1β, NFκB, p38, and JNK signaling in inflammation30–33, ETS transcription factors in MAPK signaling34,35, and NOTCH and WNT in cancer stem cells and colorectal cancer14,27,36—but other pathways that agreed with phenotypes established in our isogenic systems and pointed to previously undescribed functions. The gene discussed is MAPK8; the disease is cancer.