PI3K/Akt-GSK3β signaling contributes to neuronal growth, proliferation, and differentiation of NSCs [61]; promotes hippocampal neurogenesis in a mouse model of Alzheimer’s disease [62]; and ameliorates the apoptosis of neuronal cells in a rat model of Parkinson’s disease [63]. The gene discussed is AKT1; the disease is early-onset autosomal dominant Alzheimer disease.