None of the sites or regions from this directly overlapped regions significant in the AYATS EWAS of early-onset MD [26]; however, both this study and the AYATS EWAS identified significant DNAm regions in the major histocompatibility complex (MHC) region on chromosome 6, which was also identified in the latest PGC GWAS of depression [57]. The gene discussed is HLA-C; the disease is depressive disorder.