MLH1 and digestive system neoplasm: Patient 29 is a woman who consecutively presented three MLH1-methylated gastrointestinal tumor lesions described as a low-grade (moderately differentiated) colorectal adenocarcinoma (pT4N1) at age 22, a well-differentiated small bowel adenocarcinoma (pT4N1) at age 24, and a well-differentiated tubular adenocarcinoma of the stomach (pT2N1) at 25 years of age (Fig. 1b).