Apart from the specific clinical indications for which it is prescribed, in the scientific literature there is much evidence showing that this biological drug has also proved effective in the treatment of seasonal asthmatic exacerbations during spring and autumn [25, 26], in patients with total IgE values > 2000 kU/L [27] and even in the treatment of intrinsic severe asthma [28]. This evidence concerns the gene IGHE and asthma.