NR1H4 and colorectal cancer: In the recent years, growing studies showed that the downstream targets of FXR such as miRNAs have a potent effect on multiple cancer progression, for example, Qiao et al. demonstrated that the upregulation of FXR by GW4064, an agonist of FXR, could significantly inhibit human colorectal cancer cell proliferation via miR-135A1/CCNG2 pathway [21].