CD4 and breast cancer: In fact, attempts have been made to improve response to BCG vaccine treatment for non-muscle invasive BC using recombinant IL18-secreting BCG strain which improved the Th1 response in a murine preclinical model in addition to eliciting a better stimulation of human dendritic cells to trigger strong IFNγ secretion by naïve CD4+ lymphocytes [40, 41].