Finally, compared to the privately insured group of adults with POMCs, the publicly insured group had higher prevalence of all high-burden medical conditions for each POMC category, except for the similar or lower prevalence between neurodevelopmental POMCs for cerebrovascular diseases, POMCs of the nervous system for pain, ischemic heart diseases, cerebrovascular diseases, liver diseases, and cancer, and POMCs of other chromosomal abnormalities for pain, liver diseases, and cancer. Here, POMC is linked to cancer.