HMGCS2 and hepatocellular carcinoma: The results of immunohistochemical (IHC) staining demonstrated that HMGCS2 mainly localized at the cytoplasm and that HMGCS2 expression was decreased in nodular cirrhosis and significantly reduced in HCC tissues, while the fatty degeneration and chronic hepatitis liver tissues showed no change compared with the normal liver tissues (Figure 1A,B).