Recently, we screened deregulated NKL homeobox genes in a variety of B-cell malignancies, which included Hodgkin lymphoma (HL), follicular lymphoma (FL), diffuse large B-cell lymphoma (DLBCL), hairy cell leukemia (HCL), mantle cell lymphoma (MCL), and splenic marginal zone lymphoma (SMZL). The gene discussed is LBX1; the disease is splenic marginal zone lymphoma.