While, in T-ALL, a chromosomal translocation aberrantly activated NKX2-1 in SU-DHL-5 cells, TF HEY1 and chromatin factors KMT2A (MLL,) and particular histones, are involved in NKX2-1 deregulation [25,30]. The gene discussed is KMT2A; the disease is acute lymphoblastic leukemia.