Indeed, NETs can promote thrombus formation by presenting active TF in the setting of myocardial infarction.12 Animals treated with anti-IL-1β antibody have reduced levels of circulating MPO-DNA complexes (a marker of in vivo NETosis) after thrombus formation, as compared to vehicle-treated animals (0.082 ± 0.010 vs. 0.152 ± 0.024; p < 0.05; Figure 4A). Here, MPO is linked to myocardial infarction.