ABCA1 and Fish-eye disease: Genetic mutations in ABCA1 (Tangier disease), LCAT (familial lecithin:cholesterol acyltransferase (LCAT) deficiency, which exhibits renal disease and anemia, and fish-eye disease, which does not exhibit renal disease or anemia), ApoA1 (familial apolipoprotein (Apo) A1 deficiency), and UBIAD1 (Schnyder corneal dystrophy) all produce varying degrees of corneal cloudiness due to corneal accumulation of lipid including cholesterol [1,2,3].