Among the changes induced by the activation of αvβ3 integrin is an increase in fibronectin fibril formation that is observed in TGF-β2 and glucocorticoid-induced models of ocular hypertension or cultures treated with TGF-β2 or dexamethasone [21,22,40,41,45,166,167,168]. Here, FN1 is linked to ocular hypertension.