In the rd10 mouse retinitis pigmentosa model, inhibition of RIPK1 using Nec-1 or ripk3 gene knockout preserved cone photoreceptors and function [73], and photoreceptor necroptosis also occurs in models of age-related macular degeneration [74] and a model of retinal detachment [46]. The gene discussed is RIPK1; the disease is retinitis pigmentosa.